Research Progress of Professor Li Shengying' Research Group[ Home ]
A breakthrough titled with "Compartmentalized Biosynthesis of Mycophenolic Acid" on the biosynthesis mechanism of the first-line drug mycophenolic acid has been published online atProc. Acad. Natl. Sci. U.S.A.on Jun. 17th, 2019. The new progress was achieved in Enzyme Engineering Group directed by Li Shengying of State Key Laboratory of Microbial Technology,SDU. Prof. Li is the only corresponding author, and Prof. Zhang Wei acts as the first author. State Key Laboratory of Microbial Technology of SDU is the second corresponding affiliate.
Mycophenolic acid (MPA) from filamentous fungi is the first natural product antibiotic to be isolated and crystallized, and a first-line immunosuppressive drug for organ transplantations and autoimmune diseases. However, some key biosynthetic mechanisms of such an old and important molecule have remained unclear. The MPA biosynthetic pathway that features both compartmentalized enzymatic steps and unique cooperation between biosynthetic and